![]() ![]() Results: Recent in vitro, in vivo, and case report studies suggest psychedelic pharmacotherapies may influence the future of brain injury treatment through modulation of neuroinflammation, hippocampal neurogenesis, neuroplasticity, and brain complexity.Ĭonclusions: Historical data on the safety of some of these substances could serve in effect as phase 0 and phase I studies. Methods: Narrative mini-review of studies published related to psychedelic therapeutics and brain injury. This brief review aims to summarize the current state of the science's relevance to neurorehabilitation, and may act as a resource for those seeking to understand the precedence for these ongoing clinical trials. Recent clinical trials have begun into the use of psychedelic therapeutics for treatment of brain injury. ![]() Despite decades of investigation, pharmacologic treatment of brain injury is still a field in its infancy. Even after engaging in rehabilitation, nearly half of patients with severe TBI requiring hospitalization are left with major disability. ![]() Objective: Stroke and traumatic brain injury (TBI) are among the leading causes of disability.
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